Risks of Overinterpreting Interim Data

Risks in Randomized Controlled Trials: Role of Interim Analysis and Data Monitoring Committee.

securitization of mortality risks in life annuities

insurers have in the past few decades faced longevity risks - the risk that annuitants survive more than expected - and therefore need a new approach to manage this new risk. in this dissertation we survey methods that hedge longevity risks. these methods use securitization to manage risk, so using modern financial and insurance pricing models, especially wang transform and actuarial concepts, ...

Evaluation of monthly gridded precipitation data products ERA-Interim, PERSIANN-CDR, PERSIANN-CCS and CRU over Khuzestan province

Deficiency and inappropriate distribution of reengage station is one of challenges faced by researchers in hydrology and climate science. In this research, evaluate the applicability of four gridded precipitation data products ERA-Interim, PERSIANN-CDR, PERSIANN-CCS and CRU as a supplement or substitute for ground data in a monthly time scales. This assessment was done by comparison with observ...

Issues in data monitoring and interim analysis of trials.

OBJECTIVES To address issues about data monitoring committees (DMCs) for randomised controlled trials (RCTs). DATA SOURCES Electronic databases. Handsearching of selected books. Personal contacts with experts in the field. REVIEW METHODS Systematic literature reviews of DMCs and small group processes in decision-making; sample surveys of: reports of RCTs, recently completed and ongoing RCTs...

Interim analyses of data as they accumulate in laboratory experimentation

BACKGROUND Techniques for interim analysis, the statistical analysis of results while they are still accumulating, are highly-developed in the setting of clinical trials. But in the setting of laboratory experiments such analyses are usually conducted secretly and with no provisions for the necessary adjustments of the Type I error-rate. DISCUSSION Laboratory researchers, from ignorance or by...